Oocyte-associated transcription factors in reprogramming after somatic cell nuclear transfer: a review
نویسندگان
چکیده
منابع مشابه
I-12: Nuclear Reprogramming in Bovin Somatic Cell Nuclear Transfer
Somatic cell nuclear transfer (SCNT or cloning) returns a differentiated cell to a totipotent status; a process termed nuclear reprogramming. Reproductive cloning has potential applications in both agriculture and biomedicine, but is limited by low efficiency. To understand the deficiencies of nuclear reprogramming, our research has focused on both candidate genes and global gene expression pat...
متن کاملEpigenetic reprogramming by somatic cell nuclear transfer in primates.
We recently demonstrated that somatic cells from adult primates could be reprogrammed into a pluripotent state by somatic cell nuclear transfer. However, the low efficiency with donor cells from one monkey necessitated the need for large oocyte numbers. Here, we demonstrate nearly threefold higher blastocyst development and embryonic stem (ES) cell derivation rates with different nuclear donor ...
متن کاملInterspecies Somatic Cell Nuclear Transfer Is Dependent on Compatible Mitochondrial DNA and Reprogramming Factors
Interspecies somatic cell nuclear transfer (iSCNT) involves the transfer of a nucleus or cell from one species into the cytoplasm of an enucleated oocyte from another. Once activated, reconstructed oocytes can be cultured in vitro to blastocyst, the final stage of preimplantation development. However, they often arrest during the early stages of preimplantation development; fail to reprogramme ...
متن کاملI-8: Somatic Cell Nuclear Reprogramming byMouse Oocytes Endures Beyond ReproductiveDecline
Background: The mammalian oocyte has the unique feature of supporting fertilization and normal development while being able of reprogramming the nuclei of somatic cells towards pluripotency, and occasionally even totipotency. Whilst oocyte quality is known to decay with somatic ageing, it is not a given that different biological functions decay concurrently. In this study, we tested whether ooc...
متن کاملnetwork analysis of transcription factors for nuclear reprogramming into induced pluripotent stem cell using bioinformatics
objective: research related to induce pluripotent stem (ips) cell generation has increased rapidly in recent years. six transcription factors, namely oct4, sox2, c-myc, klf4, nanog, and lin28 have been widely used for ips cell generation. as there is a lack of data on intra- and inter-networking among these six different transcription factors, the objective of this study is to analyze the intra...
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ژورنال
عنوان ژورنال: Frontiers of Agricultural Science and Engineering
سال: 2014
ISSN: 2095-7505
DOI: 10.15302/j-fase-2014003